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Muscle Weakness
Leo Leonidas MD, FAAP
WARNING, WARNING, WARNING; This section is for my Tufts University medical students. If you are a "worrier" type or a very anxious parent, please talk to your clinician about your child's problem or symptoms, rather than reading this differential diagnosis. There is a mother in my practice who after reading about Tics in the Internet became extremely worried and vowed not to visit the Internet again and read about her sons health problem. Sometimes too much information is not good for our emotional health if we happen to be a worrier.
ACUTE ONSET
Acute Infectious Myositis
Guillain-Barre Syndrome
Trauma
Hypokalemia (loss of potassium)
Organophosphate Poisoning
Atropine Poisoning
Herpes Zoster
Infectious Mononucleosis
Poliomyelitis
Diptheria toxin
Botulism
Tick Paralysis
Epidural Abscess
Transverse Myelitis
Myoglobinuria
Polyarteritis Nodosa
Anterior Spinal Artery Occlusion
EPISODIC ACUTE ONSET
Hypokalemic Periodic Paralysis
Hyperkalemic Periodic Paralysis
Sodium-Responsive Periodic Paralysis
Periodic Paralysis with Cardiac Cysrhythmias
Paroxysmal Paralytic Myoglobinuria
Acute Intermittent Porphyria
Aldosteronism
Hyperthyroidism
McArdle Disease
Paramyotonia Congenita
SUBACUTE ONSET
Cat Scratch Disease
Thiamine Deficiency
Polymositis
Dermatomyositis
Systemic Lupus Erythematosus
Heavy Metal Poisoning (Lead, Mercury, Arsenic, Thallium, Gold, & Zinc)
Renal Disease
Steroid Myopathy
Hyperparathyroidism
Hypopituitarism
Kocher-Debre-Semelaigne Syndrome
Hyperthyroid Myopathy
Neoplasia
Brain Stem Tumor
Spinal Cord Tumor
Brain Tumor
Scleroderma
ONSET IN EARLY INFANCY
Werdnig-Hoffman Disease
Cerebral Palsy
Myathenia Gravis
Benign Congenital Hypotonia
Congenital Laxity of Ligaments
Down Syndrome
Prader-Willi Syndrome
Myotonic Dystrophy
Tay-Sachs Disease
Pompe Disease
Arthrogryoposis Multiplex Congenita
Lowe Syndrome
Myopathies
Canavan Disease
Gaucher Disease
Krabbe Disease
Generalized Gangliosidosis
Dejerine-Sottas Disease
Congenital Hypomyelination Neuropathy
Hyperlysenimia
Atonic Diplegia
Congenital Choreoathetosis and Congenital Ataxia
Glycogen Storage Disease, Type 2
Congenital Hemiplegia
Lysinuric Protein Intolerance
ONSET IN LATE INFANCY OR EARLY CHILDHOOD
Duchenne Type Muscular Dystrophy
Emotional Deprivation
Sulfatide Lipidosis (Metachromatic Leukodystrophy)
Subacute Necrotizing Encephalomyelitis
Giant Axonal Neuropathy
Ataxia-Telangiectasia
Chediak-Higashi syndrome
Refsum Disease
Craniovertebral Anomalies
Familial Spastic Paraplegia
Late Infantile Acid Maltase Deficiency
Infantile Neuroaxonal Dystrophy
Kugelberg-Welander Disease
Abetalipoproteinemia
Tangier Disease
Diaphyseal Dysplasia (Engelmann Disease)
Vitamin E Deficiency
ONSET IN LATE CHILDHOOD OR ADOLESCENCE
Myasthenia Gravis
Carnitine Deficiency
Uremia
Diabetic Neuropathy
Diastematomyelia
Charcot-Marie Tooth disease
Limb-Girdle Muscular Dystrophy
Facioscapulohumeral Dystrophy
Amyotrophic Lateral Sclerosis
Syringomyelia
Glycogen Storage Disease, Type 3
Muscle Phosphofructokinase Deficiency
Late-Onset X-linked Muscular Dystrophy (Becker)
Reference:
Signs & Symptoms in Pediatrics
2nd Edition, page 513
Tunnessen, Jr
Belly Pain Air Leaks From Lungs Acute Crying Back Pain Bed Wetting Big Lymph Node Big Spleen Blood in Urine Chronic Diarrhea Chest Pain Cough Coughing Up Blood Constipation Droopy Eye Enlarged Glands Eye Swelling Excessive Thrist Facial Paralysis Fainting Spell Feeding Problem GI Bleeding Headache Head Tilt Hives High ESR Hoarseness Joint Pain Limp Leg Pain Muscle Weakness Noisy Breathing Nose Bleeding Nose Obstruction Pyuria Recurrent Infection Red Green Urine Ringing in the Ears Scrotal Swelling Seizures Stiff Neck Swelling of the Parotic Gland Toe Walking Toeing In Toeing Out Unequal Pupils Vomiting Wheezing
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