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Henoch-Schonlein Purpura (HSP) is a hypersensitivity process affecting the small blood vessels characterized by skin rashes (petechiae and purpura) with involvement of the abdominal organs, kidney, joints, and central nervous system. Some children with HSP have seizures or headache indicating that some of the blood vessels in the brain are also involved. Others have apathy, irritability, and behavioral changes as the symptoms of HSP. The more common manifestations of HSP in children are belly pain, rashes, and blood in the urine. Most children with HSP recover without prolonged complications. Because the kidneys are sometimes involved, some children can develop high blood pressure. Leo Leonidas, MD, FAAP, Assistant Clinical Professor in Pediatrics, Tufts University School of Medicine, Boston; Attending Pediatrician, Eastern Maine Medical Center, Bangor, Maine.
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