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DOC LEO’S CLINIC

AUTISM SCREENING TEST

DOC LEO’S AUTISM QUESTIONS

Autism Spectrum Disorder (ASD) in children is characterized by reduced socialization, poor communication, and delayed language development. ASD is known to have a wide range of phenotypic manifestations—some autistic children are profoundly affected with extremely poor communication skills, while others function in school with only minor language problems and repetitive behavior (Asperger’s syndrome)—but the common denominator in all autistic children is poor social skills, especially the ability to watch and read the facial expressions of others.

This brings us to the question, "Why is poor social interaction common in children with autism?" Is poor or reduced social skills genetically or environmentally induced? Or do both genetics and environment contribute to the manifestations of ASD?

Many studies have shown that autism is grounded in genetics. Chromosomal abnormalities at the 15q11-q13 locus are frequently found in children with autistic spectrum disorder, and a "chromosome 15 phenotype" is described in patients with chromosome 15 duplications. Other suspected genes are the FOXP2, RAY1/ST7, IMMP2L, and RELN genes at 7q22-q33 as well as the GABA(A) receptor subunit and UBE3A genes on chromosome 15q11-q13.

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If most of the autistic manifestations are genetically based, can we do something about it? Unfortunately, at present, no known procedure or medication can change genetic disorders.

If autism is environmentally induced, what factors promote the autistic manifestations? So far, mercury in the diet, from eating fish, has been implicated as an agent that might contribute to ASD. Could other environmental factors enhance the manifestation of ASD in a child who is genetically predisposed to it? Or is there something in our diet that is deficient during the critical fetal development like DHA which is a major building block of the brain architecture? (Because the fear of mercury in the fish, majority of pregnant woman avoided it, hence almost no DHA in their diet.)

Since social dysfunction is the most obvious feature in children with ASD, we should ask the question, "What is the most important step an infant should go through to acquire normal social skills?"

Everybody will agree that the newborn's first skill is how to look at the mother or father's face—the eyes in particular. An infant should practice how to look at the parent's face, and watch and listen to the voice and to the words being said.

When an infant looks at the parent's face, she is activating two important areas of the brain: the right middle Fusiform gyrus (Fusiform Face Area, FFA) and the inferior occipital cortex (Occipital Face Area, OFA). These face-sensitive areas of the brain can also be detected by an Event-Related-Potential electroencephalograhy and be reflected in N170 in adults, and in N290 and P400 in young children.

Studies done by Schultz, et al, have shown that autistic individuals display hypoactive FFA when looking at a human face. This could be the reason autistic children do not look at the face when one talks to them. Because they've seldom looked directly at their parent's eyes and face, this might be why their communication and language development is negatively affected.

Autistic children did not learn how to "read" their parents' facial expressions, also failing to feel the associated emotions, because as babies they failed to watch their parents' face and mouth movements. They also did not learn the meaning of words, which delayed their language development and cognition.

DOC LEO’S CLINIC

AUTISM SCREENING TEST

DOC LEO’S AUTISM QUESTIONS

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